This demo uses moleculizer to simulate a simple, abstract signal transduction pathway. This abstract pathway was the subject of the paper "Mathematical Models of Protein Kinase Signal Transduction," by Heinrich, Neel, and Rapoport. Molecular Cell 9, 957-970,2002.
This plot shows the step-wise activation of the kinase cascade.
This plot shows the unbinding of the ligand from the receptor, along with the constant level of phosphatase. The phosphatase works to dephosphorylate all the activated protein kinases.
