Center for Quantitative Genome Function: Labs
The Alpha Project is prosecuted at four sites: MSI, MIT,
Caltech and PNNL. Highlights of the contributions from
individual Center sites, and our collaboration with the University
of Washington CEGS are summarized below.
MSI
MSI is the core of the Center and the base of the Principal
Investigator, Roger Brent. MSI leads Center efforts
to understand the quantitative behavior of the yeast pheromone
response system. The pathway is a prototypic eukaryotic signal
transduction pathway and MSI's efforts focus on coupling
experimentation and simulation to predict system behavior
over time and in response to defined perturbations. MSI leads
the training efforts of the Center and is responsible for
project management, administration and the Center's
Minority Action Plan recruitment and training program.
MIT
Drew
Endy's lab works with Center members to
develop both microfluidic devices and pathway models. In
addition the Endy lab contributes to the design of experimental
protocols that can be used to extract constrained parameter
values for pathway models. Endy's lab is also a liaison
to the open source and synthetic biology communities. Endy
contributes to the education and training of fellows, graduate
students and undergraduates.
Caltech
Jehosuha
(Shuki) Bruck's lab works with Center biologists
to both understand and formally describe information processing
in the pheromone response system. The Bruck lab also contributes
techniques for the analysis of biochemical reactions that
greatly accelerate simulations and allow for the extraction
of high-level qualitative insights. Bruck and collaborators
contribute to the education and training of fellows, graduate
students and undergraduates.
PNNL
Richard
Smith's lab works with Center biologists
to identify, quantify and follow the modification states
of pathway proteins (specifically phosphorylation) over time
and in response to defined perturbations using both mass
spectrometry and bioinformatic analyses. Smith contributes
to the education and training of fellows.
UW
Microscale Life Sciences Center - PI Diedre Meldrum
UW Microscale Life Sciences Center - In collaboration with
Center researchers, Mark Holl develops microfluidic devices
that enable MSI researchers to apply time variant inputs
of stimuli to immobilized yeast cells. These high-throughput
devices can be ported to studies using many different cell
types.
[ back to top ] |