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My research interests span every technological areas relevant to cell modeling and simulation, and include effects of non-idealistic nature of intracellular media on signaling pathways, single cell measurement techniques such as correlation spectroscopy, asynchronous discrete event simulation algorithms, and high-performance computing. My current research projects include development of high-performance Brownian Dynamics simulation algorithms for biochemical and cellular simulations, and applying the new computational methods to simulate how localization, diffusion and molecular crowding affect biochemical dynamics of cellular signaling systems such as the Alpha pathway. I am a founding steering committee member of the E-Cell Project, and am the creator / chief system architect of the cellular simulation platform E-Cell System. I am a Human Frontier Science Program Cross-disciplinary fellow.
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